Sensitization in Heart Transplantation: Emerging Knowledge A Scientific Statement From the American Heart Association

Article

关键词: PANEL-REACTIVE-ANTIBODY;    VENTRICULAR ASSIST DEVICE;    HLA CLASS-I;    LEUKOCYTE ANTIGEN ANTIBODIES;    DONOR-SPECIFIC ANTIBODIES;    CARDIAC ALLOGRAFT VASCULOPATHY;    INTRAVENOUS IMMUNE GLOBULIN;    FLOW-CYTOMETRIC DETECTION;    LONG-TERM OUTCOMES;    MEDIATED REJECTION;   

DOI  :  10.1161/CIR.0000000000000598

来源: SCIE

【 摘 要 】

Sensitization, defined as the presence of circulating antibodies, presents challenges for heart transplant recipients and physicians. When present, sensitization can limit a transplantation candidate's access to organs, prolong wait time, and, in some cases, exclude the candidate from heart transplantation altogether. The management of sensitization is not yet standardized, and current therapies have not yielded consistent results. Although current strategies involve antibody suppression and removal with intravenous immunoglobulin, plasmapheresis, and antibody therapy, newer strategies with more specific targets are being investigated.

【 授权许可】

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