期刊论文详细信息
Molecular regulation of platelet-dependent thrombosis
Article
关键词: NITRIC-OXIDE SYNTHASE;    CORONARY-ARTERY-DISEASE;    GLYCOPROTEIN-IIB-IIIA;    MONOCLONAL-ANTIBODY;    GENE POLYMORPHISMS;    ENDOTHELIAL-CELLS;    P2Y(1) RECEPTOR;    ADP RECEPTORS;    TISSUE FACTOR;    CD40 LIGAND;   
DOI  :  10.1161/CIRCULATIONAHA.104.494468
来源: SCIE
【 摘 要 】

Hemostasis is a normal process preventing the sequelae of uncontrolled hemorrhage. In certain settings, these same processes cause adverse clinical events due to thrombotic occlusion of a vessel. The majority of unstable coronary syndromes result from disruption of an atherosclerotic plaque, leading to the exposure of subintimal contents, which triggers coagulation and the formation of a platelet-rich thrombus. The central role of platelet activation in the events that lead to vessel occlusion is well known. However, this process is complex and influenced by a myriad of cellular and plasma-derived mediators that regulate the balance between occlusive and nonocclusive thrombosis.

【 授权许可】

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