Abnormalities of hemorheological, endothelial, and platelet function in patients with chronic heart failure in sinus rhythm - Effects of angiotensin-converting enzyme inhibitor and beta-blocker therapy | |
Article | |
关键词: VON-WILLEBRAND-FACTOR; MYOCARDIAL-INFARCTION; VENTRICULAR DYSFUNCTION; DILATED CARDIOMYOPATHY; HYPERCOAGULABLE STATE; HEMOSTATIC FACTORS; PLASMA-FIBRINOGEN; P-SELECTIN; DISEASE; COUNT; | |
DOI : 10.1161/01.CIR.103.13.1746 | |
来源: SCIE |
【 摘 要 】
Background-To investigate the hypothesis that abnormalities of hemorheological (fibrinogen, plasma viscosity), endothelial (von Willebrand factor [vWF]), and platelet (soluble P-selectin) function would exist in patients with chronic heart failure (CHF) who are in sinus rhythm, we conducted a cross-sectional study of 120 patients with stable CHF (median ejection fraction 30%). We also hypothesized that ACE inhibitors and beta -blockers would beneficially affect the measured indices. Methods and Results-In the cross-sectional analysis, plasma viscosity (P=0.001), fibrinogen (P=0.02), VWF (P<0.0001), and soluble P-selectin (P<0.001) levels were elevated in patients with CHF compared with healthy controls. Women demonstrated greater abnormalities of hemorheological indices and vWF than males (all P<0.05). Plasma viscosity (P=0.009) and fibrinogen (P=0.0014) levels were higher in patients with more severe symptoms (New York Heart Association [NYHA] class III-IV), but there was no relationship with left ventricular ejection fraction. When ACE inhibitors were introduced, there was a reduction in fibrinogen (repeated-measures ANOVA, P=0.016) and vWF (P=0.006) levels compared with baseline. There were no significant changes in hemorheological, endothelial, or platelet markers after the introduction of
【 授权许可】
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