Cost-effectiveness of dual-chamber pacing compared with ventricular pacing for sinus node dysfunction

Article

关键词: IMPLANTABLE CARDIOVERTER-DEFIBRILLATOR;    ACUTE MYOCARDIAL-INFARCTION;    MODE SELECTION TRIAL;    QUALITY-OF-LIFE;    TERM-FOLLOW-UP;    ATRIAL-FIBRILLATION;    SINGLE-CHAMBER;    CARDIAC-PACEMAKERS;    CANADIAN TRIAL;    HEART-FAILURE;   

DOI  :  10.1161/01.CIR.0000151810.69732.41

来源: SCIE

【 摘 要 】

Background - Compared with single-chamber ventricular pacing, dual-chamber pacing can reduce adverse events and, as a result, improve quality of life in patients paced for sick sinus syndrome. It is not clear, however, how these benefits compare with the increased cost of dual-chamber pacemakers. Methods and Results - We used 4-year data from a 2010-patient, randomized trial to estimate the incremental cost-effectiveness of dual-chamber pacing compared with ventricular pacing and then projected these findings over the patients' lifetimes by using a Markov model that was calibrated to the first 5 years of in-trial data. To assess the stability of the findings, we performed 1000 bootstrap analyses and multiple sensitivity analyses. During the first 4 years of the trial, dual-chamber pacemakers increased quality-adjusted life expectancy by 0.013 year per subject at an incremental cost-effectiveness ratio of $53 000 per quality-adjusted year of life gained. Over a lifetime, dual-chamber pacing was projected to increase quality-adjusted life expectancy by 0.14 year with an incremental cost-effectiveness ratio of approximate to$6800 per quality-adjusted year of life gained. In bootstrap analyses, dual-chamber pacing was cost-effective in 91.9% of simulations at a threshold of $50 000 per quality-adjusted year of life and in 93.2% of simulations at a threshold of $100 000. Its cost-effectiveness ratio was also below this threshold in numerous sensitivity analyses that varied key estimates. Conclusions - For patients with sick sinus syndrome requiring pacing, dual-chamber pacing increases quality-adjusted life expectancy at a cost that is generally considered acceptable.

【 授权许可】

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