Real-time magnetic resonance imaging-guided endovascular recanalization of chronic total arterial occlusion in a swine model

Article

关键词: SUPERFICIAL FEMORAL-ARTERY;    PERCUTANEOUS TRANSLUMINAL ANGIOPLASTY;    PRIMARY STENT PLACEMENT;    ATRIAL SEPTAL-DEFECTS;    BALLOON ANGIOPLASTY;    CARDIAC-CATHETERIZATION;    TRANSCATHETER CLOSURE;    INTERVENTIONAL MRI;    ILIAC ARTERIES;    ANIMAL-MODEL;   

DOI  :  10.1161/CIRCULATIONAHA.105.586727

来源: SCIE

【 摘 要 】

Background - Endovascular recanalization (guidewire traversal) of peripheral artery chronic total occlusion (CTO) can be challenging. X-ray angiography resolves CTO poorly. Virtually blind device advancement during x-ray - guided interventions can lead to procedure failure, perforation, and hemorrhage. Alternatively, MRI may delineate the artery within the occluded segment to enhance procedural safety and success. We hypothesized that real-time MRI (rtMRI) - guided CTO recanalization can be accomplished in an animal model. Methods and Results - Carotid artery CTO was created by balloon injury in 19 lipid-overfed swine. After 6 to 8 weeks, 2 underwent direct necropsy analysis for histology, 3 underwent primary x-ray - guided CTO recanalization attempts, and the remaining 14 underwent rtMRI-guided recanalization attempts in a 1.5-T interventional MRI system. Real-time MRI intervention used custom CTO catheters and guidewires that incorporated MRI receiver antennae to enhance device visibility. The mean length of the occluded segments was 13.3 +/- 1.6 cm. The rtMRI- guided CTO recanalization was successful in 11 of 14 swine and in only 1 of 3 swine with the use of x-ray alone. After unsuccessful rtMRI (n = 3), x-ray - guided attempts were also unsuccessful. Conclusions - Recanalization of long CTO is entirely feasible with the use of rtMRI guidance. Low-profile clinical-grade devices will be required to translate this experience to humans.

【 授权许可】

Free