Medical Treatment of Aortic Stenosis

Article

关键词: RENIN-ANGIOTENSIN SYSTEM;    CONVERTING-ENZYME-INHIBITORS;    LOW-DENSITY-LIPOPROTEIN;    VALVULAR HEART-DISEASE;    LEFT-VENTRICULAR HYPERTROPHY;    A REDUCTASE INHIBITORS;    ASSOCIATION TASK-FORCE;    2014 AHA/ACC GUIDELINE;    MATRIX GLA-PROTEIN;    VALVE-REPLACEMENT;   

DOI  :  10.1161/CIRCULATIONAHA.116.023997

来源: SCIE

【 摘 要 】

Untreated, severe, symptomatic aortic stenosis is associated with a dismal prognosis. The only treatment shown to improve survival is aortic valve replacement; however, before symptoms occur, aortic stenosis is preceded by a silent, latent phase characterized by a slow progression at the molecular, cellular, and tissue levels. In theory, specific medical therapy should halt aortic stenosis progression, reduce its hemodynamic repercussions on left ventricular function and remodeling, and improve clinical outcomes. In the present report, we performed a systematic review of studies focusing on the medical treatment of patients with aortic stenosis. Lipid-lowering therapy, antihypertensive drugs, and anticalcific therapy have been the main drug classes studied in this setting and are reviewed in depth. A critical appraisal of the preclinical and clinical evidence is provided, and future research avenues are presented.

【 授权许可】

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