Genome-wide linkage analysis of systolic and diastolic blood pressure - The Quebec family study

Article

关键词: ESSENTIAL-HYPERTENSION;    SINGLE-GENE;    SUSCEPTIBILITY;    SEGREGATION;    POPULATION;    TRAITS;    WOMEN;    AGE;    MEN;   

DOI  :  10.1161/01.CIR.102.16.1956

来源: SCIE

【 摘 要 】

Background-Blood pressure (BP), an important risk factor for coronary heart disease, is a complex trait with multiple genetic etiologies, While some loci affecting BP variation are known (eg, angiotensinogen), there are likely to be novel signals that can be detected with a genome scan approach. Methods and Results-A genome-wide scan was performed in 125 random and 81 obese families participating in the Quebec Family Study. A multipoint variance-components linkage analysis of 420 markers (353 microsatellites and 67 restriction fragment length polymorphisms) revealed several signals (P<0.0023) for systolic BP on 1p (D1S551, ATP1A1), 2p (D2S1790, D2S2972), 5p (D5S1986), 7q (D7S530), 8q (CRH), and 19p (D19S247). Suggestive evidence (0.0023

【 授权许可】

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