The Phosphodiesterase Inhibitor Cilostazol Induces Regression of Carotid Atherosclerosis in Subjects With Type 2 Diabetes Mellitus Principal Results of the Diabetic Atherosclerosis Prevention by Cilostazol (DAPC) Study: A Randomized Trial

Article

关键词: INTIMA-MEDIA THICKNESS;    ACTIVATED PROTEIN-KINASE;    LOW-DOSE ASPIRIN;    CARDIOVASCULAR EVENTS;    ANTIPLATELET DRUGS;    SIRT1;    INFARCTION;    STROKE;    RAT;   

DOI  :  10.1161/CIRCULATIONAHA.109.892414

来源: SCIE

【 摘 要 】

Background-Antiplatelet drugs are effective in preventing recurrence of atherosclerosis in type 2 diabetic patients. However, the efficacy and usefulness of 2 different antiplatelet drugs, aspirin and cilostazol, in the progression of carotid intima-media thickening are unknown. Methods and Results-To compare prevention by cilostazol and aspirin of progression of atherosclerosis, we conducted a prospective, randomized, open, blinded end point study in 4 East Asian countries. A total of 329 type 2 diabetic patients suspected of peripheral artery disease were allocated to either an aspirin-treated (81 to 100 mg/d) group or a cilostazol-treated (100 to 200 mg/d) group. The changes in intima-media thickness of the common carotid artery during a 2-year observation period were examined as the primary end point. The regression in maximum left, maximum right, mean left, and mean right common carotid artery intima-media thickness was significantly greater with cilostazol compared with aspirin (-0.088 +/- 0.260 versus 0.059 +/- 0.275 mm, P < 0.001; -0.042 +/- 0.274 versus 0.045 +/- 0.216 mm, P = 0.003; -0.043 +/- 0.182 versus 0.028 +/- 0.202 mm, P = 0.004; and -0.024 +/- 0.182 versus 0.048 +/- 0.169 mm, P < 0.001). In a regression analysis adjusted for possible confounding factors such as lipid levels and hemoglobin A(1c), the improvements in common carotid artery intima-media thickness with cilostazol treatment over aspirin treatment remained significant. Conclusions-Compared with aspirin, cilostazol potently inhibited progression of carotid intima-media thickness, an established surrogate marker of cardiovascular events, in patients with type 2 diabetes mellitus.

【 授权许可】

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