There is no evidence for an increase in acute coronary syndromes after short-term abrupt discontinuation of statins in stable cardiac patients

Article

关键词: NITRIC-OXIDE SYNTHASE;    PRIMARY PREVENTION;    HEART-DISEASE;    ATORVASTATIN;    WITHDRAWAL;    EVENTS;    ENDOTHELIUM;    SIMVASTATIN;    PRAVASTATIN;    EXPRESSION;   

DOI  :  10.1161/01.CIR.0000145118.55201.15

来源: SCIE

【 摘 要 】

Background - For a variety of reasons, many patients abruptly discontinue statin therapy. The present analysis was conducted to determine whether the risk of cardiovascular outcomes increases after withdrawal of statin therapy in a stable cardiac population. Methods and Results - In the Treating to New Target ( TNT) study, 2 doses of atorvastatin ( 10 and 80 mg once daily) are being used in a double-blind parallel-group design. Of the 18 468 patients screened for study participation, 16 619 entered a dietary lead-in/drug-washout period, and of these, 15 432 eligible participants began treatment with atorvastatin 10 mg/d on an open-label basis. Of the subjects who entered the dietary lead-in/drug-washout period, 57% were receiving prior statin therapy. During the 6-week drug-washout period, there were 24 primary events ( defined as coronary heart disease death, nonfatal myocardial infarction, resuscitated cardiac arrest, and fatal or nonfatal stroke); throughout the subsequent 8-week open-label period, there were 31 primary events. This equated to monthly Kaplan-Meier event rates of 0.20% during washout and 0.26% in the open-label phase. Event rates were therefore similar during the 2 phases. Conclusions - The present analysis demonstrates that short-term discontinuation of statin therapy in stable cardiac patients apparently does not lead to a clinically important increased risk of acute coronary syndromes.

【 授权许可】

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