Plasma level of B-type natriuretic peptide as a prognostic marker after acute myocardial infarction - A long-term follow-up analysis

Article

关键词: LEFT-VENTRICULAR DYSFUNCTION;    CONGESTIVE-HEART-FAILURE;    EJECTION FRACTION;    CARDIAC HORMONE;    ACUTE-PHASE;    A-TYPE;    SECRETION;    MORTALITY;    PRESSURE;    SURVIVAL;   

DOI  :  10.1161/01.CIR.0000141295.60857.30

来源: SCIE

【 摘 要 】

Background-Circulating levels of B-type natriuretic peptide (BNP), a cardiac hormone, reflect the severity of cardiac dysfunction. Because the plasma BNP level changes dramatically during the period after the onset of acute myocardial infarction (AMI), identification of a suitable sampling time is problematic. There have been several reports indicating that the plasma BNP level obtained in the acute phase of AMI can be used as a prognostic marker. We examined whether the plasma BNP level measured 3 to 4 weeks after the onset of AMI represents a reliable prognostic marker for patients with AMI. Methods and Results-We analyzed 145 consecutive patients with AMI. Plasma BNP levels were measured during the 3 to 4 weeks after onset of AMI. Of those patients, 23 experienced fatal cardiac events during this study. The mean follow-up period was 58.6 months. Log BNP, left ventricular end-diastolic pressure, and pulmonary vascular resistance were all significantly higher in the cardiac death group, and there were more men and more patients with a history of heart failure in the cardiac death group. A Cox proportional hazards model analysis showed that log BNP was an independent predictor of cardiac death. The survival rate was significantly higher in patients with log BNP <2.26 (180 pg/mL) than in those with log BNP >= 2.26. Conclusions-The plasma BNP level obtained 3 to 4 weeks after the onset of AMI can be used as an independent predictor of cardiac death in patients with AMI.

【 授权许可】

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