Mechanisms of ventricular fibrillation induction by 60-Hz alternating current in isolated swine right ventricle

Article

关键词: ELECTRICAL RESTITUTION;    CHAOS;    REPOLARIZATION;    ACTIVATION;    DISPERSION;    CELLS;    HEART;   

DOI  :  10.1161/01.CIR.102.13.1569

来源: SCIE

【 摘 要 】

Background-The mechanisms by which 60-Hz alternating current (AC) can induce ventricular fibrillation (VF) are unknown. Methods and Results-We studied 7 isolated perfused swine right ventricles in vitro. The action potential duration restitution curve was determined. Optical mapping techniques were used to determine the patterns of activation on the epicardium during 5-second 60-Hz AC stimulation (10 to 999 mu A). AC captured the right ventricles at 100 +/- 65 mu A, which is significantly lower than the direct current pacing threshold (0.77 +/- 0.45 mA, P<0.05). AC induced ventricular tachycardia or VF at 477 +/- 266 mu A, when the stimulated responses to AC had (1) short activation CLs (128 +/- 14 ms) (2) short diastolic intervals (16 +/- 9 ms), and (3) short diastolic intervals associated with a steep action potential duration restitution curve. Optical mapping studies showed that during rapid ventricular stimulation by AC, a wave front might encounter the refractory tail of an earlier wave front, resulting in the formation of a wave break and VF. Computer simulations reproduced these results. Conclusions-AC at strengths less than the regular pacing threshold can capture the ventricle at fast rates. Accidental AC leak to the ventricles could precipitate VF and sudden death if AC results in a fast ventricular rate coupled with a steep restitution curve and a nonuniform recovery of excitability of the myocardium.

【 授权许可】

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