Diabetic cardiomyopathy revisited

Review

关键词: CONGESTIVE-HEART-FAILURE;    ACTIVATED RECEPTOR-ALPHA;    CORONARY-ARTERY-DISEASE;    FATTY-ACID OXIDATION;    REDUCED CARDIAC EFFICIENCY;    LEFT-VENTRICULAR STRUCTURE;    OBESE ZUCKER RATS;    BB WOR RAT;    INSULIN-RESISTANCE;    CONTRACTILE DYSFUNCTION;   

DOI  :  10.1161/CIRCULATIONAHA.106.679597

来源: SCIE

【 摘 要 】

Diabetes mellitus increases the risk of heart failure independently of underlying coronary artery disease, and many believe that diabetes leads to cardiomyopathy. The underlying pathogenesis is partially understood. Several factors may contribute to the development of cardiac dysfunction in the absence of coronary artery disease in diabetes mellitus. This review discusses the latest findings in diabetic humans and in animal models and reviews emerging new mechanisms that may be involved in the development and progression of cardiac dysfunction in diabetes.

【 授权许可】

Free