期刊论文详细信息
Low-dose transdermal testosterone therapy improves angina threshold in men with chronic stable angina - A randomized, double-blind, placebo-controlled study
Article
关键词: CORONARY-ARTERY DISEASE;    MYOCARDIAL-ISCHEMIA;    CONTROLLED TRIAL;    HEART-DISEASE;    PECTORIS;    SYSTEM;   
DOI  :  10.1161/01.CIR.102.16.1906
来源: SCIE
【 摘 要 】

Background-Experimental studies suggest that androgens induce coronary vasodilatation. We performed this pilot project to examine the clinical effects of long-term low-dose androgens in men with angina. Methods and Results-Forty-six men with stable angina completed a 2-week, single-blind placebo run-in, followed by double-blind randomization to 5 mg testosterone daily by transdermal patch or matching placebo for 12 weeks, in addition to their current medication. Time to l-mm ST-segment depression on treadmill exercise testing and hormone levels were measured and quality of life was assessed by SF-36 at baseline and after 4 and 12 weeks of treatment. Active treatment resulted in a 2-fold increase in androgen levels and an increase in time to l-mm ST-segment depression from (mean+/-SEM) 309+/-27 seconds at baseline to 343+/-26 seconds after 4 weeks and to 361+/-22 seconds after 12 weeks. This change was statistically significant compared with that seen in the placebo group (from 266+/-25 seconds at baseline to 284+/-23 seconds after 4 weeks and to 292+/-24 seconds after 12 weeks; P=0.02 between the 2 groups by ANCOVA). The magnitude of the response was greater in those with lower baseline levels of bioavailable testosterone (r=-0.455, P<0.05). There were no significant changes in prostate specific antigen, hemoglobin, lipids, or coagulation profiles during the study. There were significant improvements in pain perception (P=0.026) and role limitation resulting from physical problems (P=0.024) in the testosterone-treated group. Conclusions-Low-dose supplemental testosterone treatment in men with chronic stable angina reduces exercise-induced myocardial ischemia.

【 授权许可】

Free   

  文献评价指标  
  下载次数:0次 浏览次数:2次