Long-term results after the glycoprotein IIb/IIIa inhibitor abciximab in unstable angina - One-year survival in the GUSTO IV-ACS (global use of strategies to open occluded coronary arteries IV - Acute coronary syndrome) trial

Article

关键词: ST-SEGMENT ELEVATION;    MYOCARDIAL-INFARCTION;    TASK-FORCE;    PLATELET;    RECOMMENDATIONS;    STREPTOKINASE;    EPTIFIBATIDE;    MANAGEMENT;    BLOCKADE;    EFFICACY;   

DOI  :  10.1161/01.CIR.0000046487.06811.5E

来源: SCIE

【 摘 要 】

Background-This study was designed to investigate long-term effects of the glycoprotein IIb/IIIa inhibitor abciximab in patients with acute coronary syndrome without ST elevation who were not scheduled for coronary intervention. Methods and Results-A total of 7800 patients were included with an acute coronary syndrome without ST elevation, documented by either elevated cardiac troponin or transient or persistent ST-segment depression. They were randomized to abciximab bolus and 24-hour infusion, abciximab bolus and 48-hour infusion, or matching placebo. The overall 1-year mortality rate was 8.3% (649 patients). One-year mortality was 7.8% in the placebo group and 8.2% in the 24-hour and 9.0% in the 48-hour abciximab infusion group. Compared with placebo, the hazard ratio for the 24-hour infusion of abciximab was 1.1 (95% CI 0.86 to 1.29), and for the 48-hour infusion, it was 1.2 (95% CI 0.95 to 1.41). The lack of benefit of abciximab was observed in every subgroup studied. Patients with negative troponin or elevated C-reactive protein had a higher mortality rate after treatment with abciximab for 48 hours than with placebo: 8.5% versus 5.8% in those with negative troponin (P=0.02), 16.3% versus 12.1% in those with elevated C-reactive protein (P=0.04). Conclusions-Compared with placebo, abciximab did not provide any survival benefit at I year in patients admitted with an acute coronary syndrome with ST depression and/or elevated troponin who were not scheduled to undergo early coronary revascularization. In subgroups of patients, in particular those with low cardiac troponin or elevated C-reactive protein, abciximab was associated with excess mortality.

【 授权许可】

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