Pathological Ventricular Remodeling: Mechanisms: Part 1 of 2

Article

关键词: PRESERVED EJECTION FRACTION;    CHRONIC HEART-FAILURE;    CARDIOVASCULAR MAGNETIC-RESONANCE;    TO-MESENCHYMAL TRANSITION;    CARDIAC-HYPERTROPHY;    ANGIOTENSIN-II;    MYOCARDIAL-INFARCTION;    NATRIURETIC PEPTIDE;    PROTEIN-KINASE;    INTRAVENOUS IMMUNOGLOBULIN;   

DOI  :  10.1161/CIRCULATIONAHA.113.001878

来源: SCIE

【 摘 要 】

Despite declines in heart failure morbidity and mortality with current therapies, rehospitalization rates remain distressingly high, substantially affecting individuals, society, and the economy. As a result, the need for new therapeutic advances and novel medical devices is urgent. Disease-related left ventricular remodeling is a complex process involving cardiac myocyte growth and death, vascular rarefaction, fibrosis, inflammation, and electrophysiological remodeling. Because these events are highly interrelated, targeting a single molecule or process may not be sufficient. Here, we review molecular and cellular mechanisms governing pathological ventricular remodeling.

【 授权许可】

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