Functional recovery of stroke rats induced by granulocyte colony-stimulating factor-stimulated stem cells

Article

关键词: MARROW STROMAL CELLS;    BONE-MARROW;    NEURONAL PLASTICITY;    NEUROTROPHIC FACTOR;    PERIPHERAL-BLOOD;    ADULT-RAT;    FACTOR-I;    PROLIFERATION;    ISCHEMIA;    SURVIVAL;   

DOI  :  10.1161/01.CIR.0000142616.07367.66

来源: SCIE

【 摘 要 】

Background-Stroke is a leading cause of death and disability worldwide; however, no effective treatment currently exists. Methods and Results-Rats receiving subcutaneous granulocyte colony-stimulating factor (G-CSF) showed less cerebral infarction, as evaluated by MRI, and improved motor performance after right middle cerebral artery ligation than vehicle-treated control rats. Subcutaneous administration of G-CSF enhanced the availability of circulating hematopoietic stem cells to the brain and their capacity for neurogenesis and angiogenesis in rats with cerebral ischemia. Conclusions-G-CSF induced increases in bone marrow cell mobilization and targeting to the brain, reducing the volume of cerebral infarction and improving neural plasticity and vascularization.

【 授权许可】

Free