Serum Long-Chain n-3 Polyunsaturated Fatty Acids and Risk of Hospital Diagnosis of Atrial Fibrillation in Men

Article

关键词: HEART-RATE-VARIABILITY;    ALPHA-LINOLENIC ACID;    ACUTE CORONARY EVENTS;    EASTERN FINNISH MEN;    MIDDLE-AGED MEN;    FISH-OIL;    MYOCARDIAL-INFARCTION;    DOCOSAHEXAENOIC ACID;    EICOSAPENTAENOIC ACID;    CARDIOVASCULAR-DISEASE;   

DOI  :  10.1161/CIRCULATIONAHA.109.852657

来源: SCIE

【 摘 要 】

Background-Atrial fibrillation (AF) is a common cardiac arrhythmia. Regular fish consumption has been shown to reduce the risk of AF in some but not all studies. Long-chain n-3 polyunsaturated fatty acids (PUFAs) from fish have been suggested to account for these beneficial effects. We tested this hypothesis by studying the association between the serum long-chain n-3 PUFAs eicosapentaenoic acid, docosapentaenoic acid, and docosahexaenoic acid and risk of AF in men. Methods and Results-A total of 2174 men from the prospective population-based Kuopio Ischemic Heart Disease Risk Factor Study, 42 to 60 years old and free of AF at baseline in 1984 to 1989, were studied. During the average follow-up time of 17.7 years, 240 AF events occurred. In the Cox proportional hazards model, the multivariable-adjusted hazard ratio in the highest (>5.33%) versus the lowest (<3.61%) quartile of eicosapentaenoic acid plus docosapentaenoic acid plus docosahexaenoic acid was 0.65 (95% confidence interval 0.44 to 0.96, P for trend = 0.07). Evaluated individually, only serum docosahexaenoic acid was associated with the risk of AF ( hazard ratio in the highest versus the lowest quartile 0.62, 95% confidence interval 0.42 to 0.92, P for trend = 0.02). Exclusion of subjects (n = 233) with myocardial infarction or congestive heart failure either at baseline or that preceded the AF event during follow-up slightly strengthened the associations. Serum intermediate chain-length n-3 PUFA, alpha-linolenic acid, or hair methylmercury concentration were not associated with the risk. Conclusions-An increased concentration of long-chain n-3 PUFAs in serum, a marker of fish or fish oil consumption, may protect against AF. Serum docosahexaenoic acid concentration had the greatest impact. (Circulation. 2009; 120:2315-2321.)

【 授权许可】

Free