Chlamydia pneumoniae infection and early asymptomatic carotid atherosclerosis

Article

关键词: CORONARY HEART-DISEASE;    INTIMA-MEDIA THICKNESS;    CARDIOVASCULAR RISK-FACTORS;    MYOCARDIAL-INFARCTION;    ARTERY WALL;    ULTRASOUND;    ASSOCIATION;    VARIABILITY;    STENOSIS;    STROKE;   

DOI  :  10.1161/01.CIR.100.8.832

来源: SCIE

【 摘 要 】

Background-Chronic Chlamydia pneumoniae infection has been implicated in the pathogenesis of atherosclerosis but whether it plays a role at an early stage in the disease is uncertain. An early estimate of atherosclerosis can be obtained by ultrasonic imaging of the carotid artery to determine intima-media thickness (IMT) and the thickness of any atheroma plaques. Methods and Results-In 983 normal population individuals aged 30 to 70 years, we measured common carotid artery (CCA) and carotid bulb IMT, and also carotid plaque thickness and the degree of internal carotid artery (ICA) stenosis, C. pneumoniae IgA titers of greater than or equal to 16 and IgG titers of greater than or equal to 64 were taken as positive. There was no association between C. pneumoniae IgA or IgG seropositivity with right, left, or mean CCA or bulb IMT, or with the presence of carotid plaques, There was a significant association between IgA seropositivity and >50% mean carotid stenosis with an odds ratio of 5.24 (95% CI 1.24 to 22.21, P=0.0245) after controlling for age and sex; after controlling for other cardiovascular risk factors, this was not significant 3-96 (95% CI 0.84 to 18.78, P=0.082). No association was found between IgA or Ige seropositivity and markers of fibrinogen, log C-reactive protein, or leukocyte count. Conclusions-We found no evidence that serological evidence of C, pneumoniae infection is associated with early atherosclerosis. It is possible that IgA seropositivity is associated with more advanced disease but this hypothesis needs to be examined in a population with a higher prevalence of advanced atherosclerosis. We found no evidence that C. pneumoniae results in a chronic systemic inflammatory state.

【 授权许可】

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