Offspring of normal and diabetic rats fed saturated fat in pregnancy demonstrate vascular dysfunction

Article

关键词: ENDOTHELIUM-DEPENDENT RELAXATION;    RESISTANCE ARTERIES;    BLOOD-PRESSURE;    METABOLISM;    LACTATION;    NUTRITION;    MELLITUS;    VESSELS;    GROWTH;    DIETS;   

DOI  :  10.1161/01.CIR.98.25.2899

来源: SCIE

【 摘 要 】

Background-Disturbances of the in utero environment may program for disease ill later life. In this study, we determined whether dietary fat supplementation and/or diabetes in pregnancy can adversely affect vascular function in the offspring. Methods and Results-Female Sprague-Dawley rats were fed a breeding diet or a diet high in saturated fat (30% wt/wt) for 10 days before mating, throughout pregnancy, and postpartum. Endothelium-dependent relaxation to acetylcholine was blunted in isolated femoral arteries of 15-day-old weanling pups from dams fed the 30%-fat diet. Endothelial dysfunction and enhanced constrictor responses to norepinephrine were also observed in an additional study of 60-day-old offspring of dams fed 20% saturated fat. Rats with streptozotocin-induced diabetes were also fed saturated fat during pregnancy, Femoral arteries from their 15-day-old offspring showed impairment of endothelium-dependent dilation and enhanced constrictor responses to norepinephrine and the thromboxane mimetic U46619 compared with young offspring of high-fat-fed normal dams, The 30%-fat diet was also deleterious to vascular function in the maternal diabetic animals when assessed in mesenteric arteries 16 days postpartum, Conclusions-A high-fat diet in pregnancy led to vascular dysfunction in rat weanlings and young adult offspring. Vascular function further deteriorated in weanlings if the maternal rat was diabetic.

【 授权许可】

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