Safety of statins - Focus on clinical pharmacokinetics and drug interactions

Article

关键词: INCREASES SERUM CONCENTRATIONS;    COA REDUCTASE INHIBITORS;    GRAPEFRUIT JUICE;    SIMVASTATIN INTERACTION;    PLATELET INHIBITION;    RHABDOMYOLYSIS;    ATORVASTATIN;    PRAVASTATIN;    LOVASTATIN;    EFFICACY;   

DOI  :  10.1161/01.CIR.0000131519.15067.1f

来源: SCIE

【 摘 要 】

Statin monotherapy is generally well tolerated, with a low frequency of adverse events. The most important adverse effects associated with statins are myopathy and an asymptomatic increase in hepatic transaminases, both of which occur infrequently. Because statins are prescribed on a long-term basis, however, possible interactions with other drugs deserve particular attention, as many patients will typically receive pharmacological therapy for concomitant conditions during the course of statin treatment. This review summarizes the pharmacokinetic properties of statins and emphasizes their clinically relevant drug interactions.

【 授权许可】

Free