Hedgehog morphogen in cardiovascular disease

Article

关键词: LEFT-RIGHT ASYMMETRY;    SONIC-HEDGEHOG;    POLARIZING ACTIVITY;    RETINOIC ACID;    PATHWAYS;    MOUSE;    GENE;    IDENTIFICATION;    DROSOPHILA;    PROTEINS;   

DOI  :  10.1161/CIRCULATIONAHA.106.619213

来源: SCIE

【 摘 要 】

In this review, we focus on the basic biology of the important developmental Hedgehog ( Hh) protein family, its general function in development, pathway mechanisms, and gene discovery and nomenclature. Hh function in cardiovascular development and recent findings concerning Hh signaling in ischemia models are discussed in more detail, and future perspectives are proposed. In light of the recent discovery of Hh transport by insect lipophorin, we also hypothesize a role for low-density lipoprotein ( LDL) in mammalian Hh transport, creating a surprising role for LDL in cardiovascular disease.

【 授权许可】

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