Efficacy and safety of oral dofetilide in converting to and maintaining sinus rhythm in patients with chronic atrial fibrillation or atrial flutter - The Symptomatic Atrial Fibrillation Investigative Research on Dofetilide (SAFIRE-D) study

Article

关键词: LEFT-VENTRICULAR DYSFUNCTION;    MYOCARDIAL-INFARCTION;    ANTIARRHYTHMIC DRUG;    RANDOMIZED TRIAL;    THERAPY;    AMIODARONE;    QUINIDINE;    MORTALITY;    UK-68,798;   

DOI  :  10.1161/01.CIR.102.19.2385

来源: SCIE

【 摘 要 】

Background-This double-blind, multicenter, placebo-controlled study determined the efficacy and safety of dofetilide in converting atrial fibrillation (AF) or atrial flutter (AFl) to sinus rhythm (SR) and maintaining SR for 1 year. Methods and Results-Patients with AF or AFl (n=325) were randomized to 125, 2501 or 500 mug dofetilide or placebo twice daily. Dosages were adjusted for QTc response and, after 105 patients were enrolled, for calculated creatinine clearance (Cl-Cr). Pharmacological cardioversion rates for 125, 250, and 500 mug dofetilide were 6.1%, 9.8%, and 29.9%, respectively, versus 1.2% for placebo (250 and 500 mug versus placebo; P=0.015 and P<0.001, respectively). Seventy percent of pharmacological cardioversions with dofetilide were achieved in 24 hours and 91% in 36 hours. For the 250 patients who successfully cardioverted pharmacologically or electrically, the probability of remaining in SR at 1 year was 0.40, 0.37, 0.58 for 125, 250, and 500 g dofetilide, respectively, and 0.25 for placebo (500 mug versus placebo, P=0.001). Two cases of torsade de pointes occurred, 1 on day 2 and the other on day 3 (0.8% of all patients given active drug); 1 sudden cardiac death, classified as proarrhythmic, occurred on day 8 (0.4% of all patients given active drug). Conclusion-Dofetilide, a new class III antiarrhythmic agent, is moderately effective in cardioverting AF or AFl to SR and significantly effective in maintaining SR for 1 year. In-hospital initiation and dosage adjustment based on QTc and Cl-Cr are necessary to minimize a small but nonnegligible proarrhythmic risk.

【 授权许可】

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