Comparison of Drug-Eluting Stents and Coronary Artery Bypass Surgery for the Treatment of Multivessel Coronary Disease Three-Year Follow-Up Results From a Single Institution

Article

关键词: BARE-METAL STENTS;    LONG-TERM OUTCOMES;    RANDOMIZED CONTROLLED-TRIAL;    TAXUS-IV TRIAL;    SLOW-RELEASE;    CLINICAL-OUTCOMES;    PROPENSITY SCORE;    STANDARD STENT;    SIROLIMUS;    INTERVENTION;   

DOI  :  10.1161/CIRCULATIONAHA.108.819730

来源: SCIE

【 摘 要 】

Background-Numerous studies have compared the outcomes of coronary artery bypass grafting (CABG) surgery and coronary stenting for the treatment of multivessel coronary disease. In 2003, drug-eluting stents were introduced with the hope of reducing restenosis. However, limited information exists on the comparison of drug-eluting stents and CABG surgery. The long-term outcome of drug-eluting stents compared with that of CABG surgery is also unclear. Methods and Results-We identified 3720 consecutive patients with multivessel disease who underwent isolated CABG surgery or received drug-eluting stents between April 1, 2004, and December 31, 2005, and we compared safety (total mortality, myocardial infarction, and stroke) and efficacy (target-vessel revascularization) during a 3-year follow-up. These outcomes were compared after adjustment for differences in baseline risk factors. Patients who underwent CABG (n = 1886) were older and had more comorbidities than patients who received drug-eluting stents (n = 1834). Patients receiving drug-eluting stents had considerably higher 3-year rates of target-vessel revascularization. Drug-eluting stents were also associated with higher rates of death (adjusted hazard ratio, 1.62; 95% confidence interval, 1.07 to 2.47) and myocardial infarction (adjusted hazard ratio, 1.65; 95% confidence interval, 1.15 to 2.44). The risk adjusted rate of stroke was similar in the 2 groups (hazard ratio, 0.92; 95% confidence interval, 0.69 to 1.51). Conclusions-In a cohort of patients with multivessel disease, CABG was associated with lower rates of death, myocardial infarction, and target-vessel revascularization than drug-eluting stents. (Circulation. 2009; 119: 2040-2050.)

【 授权许可】

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