Prevalence and Clinical Significance of Aortic Root Dilation in Highly Trained Competitive Athletes

Article

关键词: MITRAL-VALVE-PROLAPSE;    DOPPLER-ECHOCARDIOGRAPHY;    HEART;    DILATATION;    CRITERIA;    RECOMMENDATIONS;    REGURGITATION;    SIZE;   

DOI  :  10.1161/CIRCULATIONAHA.109.901074

来源: SCIE

【 摘 要 】

Background-Few data are available that address the impact of athletic training on aortic root size. We investigated the distribution, determinants, and clinical significance of aortic root dimension in a large population of highly trained athletes. Methods and Results-Transverse aortic dimensions were assessed in 2317 athletes (56% male), free of cardiovascular disease, aged 24.8 +/- 6.1 (range, 9 to 59) years, engaged in 28 sports disciplines (28% participated in Olympic Games). In males, aortic root was 32.2 +/- 2.7 mm (range, 23 to 44; 99th percentile=40 mm); in females, aortic root was 27.5 +/- 2.6 mm (range, 20 to 36; 99th percentile=34 mm). Aortic root was enlarged >= 40 mm in 17 male (1.3%) and >= 34 mm in 10 female (0.9%) subjects. Over an 8-year follow-up period, aortic dimension increased in these male athletes (40.9 +/- 1.3 to 42.9 +/- 3.6 mm; P<0.01) and dilated substantially (to 50, 50, and 48 mm) in 3, after 15 to 17 years of follow-up, in the absence of systemic disease. Aortic root did not increase significantly (34.9 +/- 0.9 to 35.4 +/- 2.1 mm; P=0.11) in female athletes. Multiple regression and covariance analysis showed that aortic dimension was largely explained by weight, height, left ventricular mass, and age (R-2=0.63; P<0.001), with type of sports training having a significant but lower impact (P<0.003). Conclusions-An aortic root dimension >40 mm in highly conditioned male athletes (and >34 mm in female athletes) is uncommon, is unlikely to represent the physiological consequence of exercise training, and is most likely an expression of a pathological condition, mandating close clinical surveillance. (Circulation. 2010;122:698-706.)

【 授权许可】

Free