Effect of 3 months of antimicrobial treatment with clarithromycin in acute non-Q-wave coronary syndrome

Article

关键词: CHLAMYDIA-PNEUMONIAE INFECTION;    SECONDARY PREVENTION TRIAL;    MYOCARDIAL-INFARCTION;    SEROLOGICAL EVIDENCE;    ARTERY-DISEASE;    RISK-FACTOR;    ATHEROSCLEROSIS;    ROXITHROMYCIN;    AZITHROMYCIN;   

DOI  :  10.1161/01.CIR.0000012544.07696.1F

来源: SCIE

【 摘 要 】

Background-Coronary artery disease, an inflammatory disease, may be caused by infection. We investigated whether the antibiotic clarithromycin would reduce morbidity and mortality in patients with acute non-Q-wave coronary syndrome. Methods and Results-Altogether, 148 patients with acute non-Q-wave infarction or unstable angina were randomly assigned to receive double-blind treatment with either clarithromycin or placebo for 3 months. The primary end point was a composite of death, myocardial infarction, or unstable angina during treatment; the secondary end point was occurrence of any cardiovascular event during the entire follow-up period (average 555 days, range 138 to 924 days). There was a trend toward fewer patients meeting primary end-point criteria in the clarithromycin group than in the placebo group (11 versus 19 patients, respectively; risk ratio 0.54, 95% CI 0.25 to 1.14; P=0.10). By the end of the entire follow-up, 16 patients in the clarithromycin group and 27 in the placebo group had experienced a cardiovascular event (risk ratio 0.49, 95% CI 0.26 to 0.92; P=0.03). Conclusions-Clarithromycin appears to reduce the risk of ischemic cardiovascular events in patients presenting with acute non-Q-wave infarction or unstable angina. No signs of this effect diminishing were observed during follow-up.

【 授权许可】

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