Phase 2 reentry as a trigger to initiate ventricular fibrillation during early acute myocardial ischemia

Article

关键词: ST-SEGMENT ELEVATION;    CELLULAR BASIS;    BRUGADA-SYNDROME;    INTRACELLULAR-RECORDINGS;    CARDIAC DEATH;    INFARCTION;    ARRHYTHMIAS;    MECHANISMS;    ARRHYTHMOGENESIS;    TACHYCARDIA;   

DOI  :  10.1161/01.CIR.0000140258.09964.19

来源: SCIE

【 摘 要 】

Background-Phase 2 reentry caused by heterogeneous loss of the transient outward potassium current (I-to)-mediated epicardial action potential (AP) dome can produce a closely coupled R-on-T extrasystole leading to ventricular fibrillation (VF) under conditions of ST-segment elevation unrelated to ischemia. The present study examined the role of phase 2 reentry in the initiation of VF during early myocardial ischemia. Methods and Results-Regional myocardial ischemia was produced in an isolated, arterially perfused canine right ventricular wedge preparation. Transmembrane APs from 2 epicardial sites at each side of the ischemic border were simultaneously recorded together with measurements of extracellular potassium concentration ([K+](o)) and a transmural ECG. Loss of the I-to-mediated epicardial AP dome in the ischemic zone but not in the perfused tissue resulted in phase 2 reentry and associated R-on-T extrasystoles capable of initiating VF in 7 of 15 preparations during the first 3 to 9 minutes of myocardial ischemia, with marked ST-segment elevation and [K+](o) accumulation. The I-to and phase 1 magnitude of epicardium contributed importantly to the onset of VF. Phase 1 magnitude and I-to density at +30 mV in the group with phase 2 reentry-related R-on-T extrasystoles were 32.2+/-1.3 mV and 30.3+/-0.5 pA/pF (n=7), respectively, significantly greater than those (24.0+/-1.8 mV and 23.2+/-1.0 pA/pF) in the group without the extrasystoles (n=8, P<0.01). Conclusions-Acute regional myocardial ischemia results in markedly heterogeneous loss of I-to-mediated epicardial AP domes across the ischemic border, leading to phase 2 reentry. Phase 2 reentry can in turn produce an R-on-T extrasystole capable of initiating VF.

【 授权许可】

Free