Sildenafil in the treatment of Raynaud's phenomenon resistant to vasodilatory therapy

Article

关键词: ORAL SILDENAFIL;    INHALED ILOPROST;    NITRIC-OXIDE;    HYPOXIA;    DISEASE;   

DOI  :  10.1161/CIRCULATIONAHA.104.523324

来源: SCIE

【 摘 要 】

Background-Vasodilatory therapy of Raynaud's phenomenon represents a difficult clinical problem because treatment often remains inefficient and may be not tolerated because of side effects. Methods and Results-To investigate the effects of sildenafil on symptoms and capillary perfusion in patients with Raynaud's phenomenon, we performed a double-blinded, placebo-controlled, fixed-dose, crossover study in 16 patients with symptomatic secondary Raynaud's phenomenon resistant to vasodilatory therapy. Patients were treated with 50 mg sildenafil or placebo twice daily for 4 weeks. Symptoms were assessed by diary cards including a 10-point Raynaud's Condition Score. Capillary flow velocity was measured in digital nailfold capillaries by means of a laser Doppler anemometer. While taking sildenafil, the mean frequency of Raynaud attacks was significantly lower (35 +/- 14 versus 52 +/- 18, P = 0.0064), the cumulative attack duration was significantly shorter (581 +/- 133 versus 1046 +/- 245 minutes, P = 0.0038), and the mean Raynaud's Condition Score was significantly lower (2.2 +/- 0.4 versus 3.0 +/- 0.5, P = 0.0386). Capillary blood flow velocity increased in each individual patient, and the mean capillary flow velocity of all patients more than quadrupled after treatment with sildenafil (0.53 +/- 0.09 versus 0.13 coproduct 0.02 mm/s, P = 0.0004). Two patients reported side effects leading to discontinuation of the study drug. Conclusions-Sildenafil is an effective and well-tolerated treatment in patients with Raynaud's phenomenon.

【 授权许可】

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