Expression of lectinlike oxidized low-density lipoprotein receptor-1 in human atherosclerotic lesions

Article

关键词: MACROPHAGE SCAVENGER RECEPTOR;    INTERCELLULAR-ADHESION MOLECULE-1;    VASCULAR ENDOTHELIAL-CELLS;    CORONARY ATHEROSCLEROSIS;    APOPTOTIC THYMOCYTES;    LDL RECEPTOR-1;    MESSENGER-RNA;    P-SELECTIN;    HUMAN CD68;    IN-VITRO;   

DOI  :  10.1161/01.CIR.99.24.3110

来源: SCIE

【 摘 要 】

Background-Oxidized LDL (Ox-LDL) seems to play key roles in atherogenesis, Lectinlike Ox-LDL receptor-1 (LOX-1) is a recently identified cell-surface receptor for Ox-LDL. The relationship of this novel receptor for Ox-LDL to atherogenesis, however, has not yet been clarified. In this study, we explored the expression of LOX-1 in the atherosclerotic lesions of human carotid arteries. Methods and Results-Using carotid endarterectomy specimens obtained from 21 patients and 2 samples of normal human aortas, we examined LOX-1 expression by reverse transcription-polymerase chain reaction and immunohistochemistry. In aortas without atherosclerosis, LOX-1 expression was undetectable by immunohistochemistry and negligible by reverse transcription-polymerase chain reaction. In carotid arteries, luminal endothelial cells covering early atherosclerotic lesions were more frequently positive for LOX-1 expression than those in advanced atherosclerotic lesions, Endothelial cells in the intimal neovasculature of advanced lesions also expressed LOX-1. In addition, macrophages and smooth muscle cells in the intima of advanced atherosclerotic plaques were positive for LOX-1 expression. Conclusions-LOX-1 may play important roles in Ox-LDL uptake and subsequent functional alteration in the luminal endothelium in early atherosclerotic lesions and in intimal neovascular endothelial cells in advanced plaques. Furthermore, LOX-1 may also be involved in Ox-LDL uptake and subsequent foam cell transformation in macrophages and smooth muscle cells in the atherosclerotic intima.

【 授权许可】

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