Heterogeneous sympathetic innervation influences local myocardial repolarization in normally perfused rabbit hearts | |
Article | |
关键词: ACTIVATION-RECOVERY INTERVALS; ACTION-POTENTIAL DURATIONS; VENTRICULAR-TACHYCARDIA; DENERVATION SUPERSENSITIVITY; REFRACTORINESS; INFARCTION; DISPERSION; INVIVO; INTERVENTIONS; ELECTROGRAMS; | |
DOI : 10.1161/01.CIR.101.9.1060 | |
来源: SCIE |
【 摘 要 】
Background-Heterogeneity of sympathetic innervation is thought to contribute to the potential for fatal arrhythmia. However, little is known about the effects of heterogeneous innervation on repolarization. Methods and Results-To assess this relationship, we measured activation recovery intervals (ARIs) from 64 epicardial sites in 11 rabbits studied 2 weeks after regional denervation produced by phenol and 4 sham-operated rabbits. ARI results were compared with the distribution of sympathetic innervation measured from 3D reconstructions of serial autoradiographs of [I-125]metaiodobenzylguanidine and Tc-99m-sestamibi. ARIs were recorded during baseline sinus rhythm, norepinephrine (NE) infusion (0.1 mu g.kg(-1) min(-1)), and left stellate ganglion stimulation (SS). NE shortened ARI in 98% of electrodes in the denervated region. The degree of ART shortening and dispersion increased (P<0.001 and P<0.01, respectively) as denervation became more severe. SS shortened ARI in 30% of electrodes in the denervated area, with increased shortening and dispersion related to increased severity of denervation (P<0.01). SS prolonged ARI in 70% of electrodes in the denervated area, with no correlation with severity of denervation. Conclusions-The magnitude and dispersion of local repolarization responses are related to the severity of denervation, as well as the type of stimulation: neural (SS) versus humoral (NE). The differences may relate to the concentration of NE released.
【 授权许可】
Free