Vessel dilator enhances sodium and water excretion and has beneficial hemodynamic effects in persons with congestive heart failure

Article

关键词: ATRIAL-NATRIURETIC-FACTOR;    C-TERMINAL PORTIONS;    INDUCED CENTRAL HYPERVOLEMIA;    FACTOR PROHORMONE;    N-TERMINUS;    INCREASED RELEASE;    3 PEPTIDES;    HUMANS;    DOGS;    EXPRESSION;   

DOI  :  10.1161/01.CIR.98.4.323

来源: SCIE

【 摘 要 】

Background-Vessel dilator, a 37-amino acid peptide hormone synthesized in the heart, enhances urine flow 4- to 12-fold and sodium excretion 3- to 6-fold in healthy humans. The present investigation was designed to determine whether vessel dilator might have similar beneficial effects in persons with congestive heart failure (CHF). Methods and Results-Vessel dilator (100 ng/kg body weight per minute) given intravenously for 60 minutes to NYHA class III CHF subjects increased urine flow 2- to 13-fold, which was still increased (P<0,001) 3 :hours after its infusion was stopped. Vessel dilator enhanced sodium excretion 3- to 4-fold in CHF subjects (P<0.01), which was still significantly (P<0,01) elevated 3 hours after infusion. Vessel dilator decreased systemic vascular resistance 24%, pulmonary vascular resistance 25%, pulmonary capillary wedge pressure 33%, and central venous pressure 27% while increasing cardiac output 34%, cardiac index 35%, and stroke volume index 24% without significantly affecting heart rate or pulmonary artery pressure in the CHF subjects. The control CHF patients did not have any changes in the above parameters. Conclusions-These results indicate that vessel dilator has significant beneficial diuretic, natriuretic, and hemodynamic properties in humans with congestive heart failure.

【 授权许可】

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