alpha-Adrenergic coronary vasoconstriction and myocardial ischemia in humans

Article

关键词: LEFT-VENTRICULAR DYSFUNCTION;    ANGINA-PECTORIS;    ARTERY DISEASE;    VASCULAR-RESISTANCE;    BLOOD-FLOW;    ENDOTHELIAL DYSFUNCTION;    CONSCIOUS DOGS;    MENTAL STRESS;    LONG-TERM;    EXERCISE;   

DOI  :  10.1161/01.CIR.101.6.689

来源: SCIE

【 摘 要 】

The use of quantitative coronary angiography, combined with Doppler and PET, has recently been directed at the study of alpha-adrenergic coronary vasomotion in humans. Confirming prior animal experiments, there is no evidence of alpha-adrenergic coronary constrictor tone at rest. Again confirming prior experiments, responses to alpha-adrenoceptor activation are augmented in the presence of coronary endothelial dysfunction and atherosclerosis, involving both alpha(1)- and alpha(2)-adrenoceptors in epicardial conduit arteries and microvessels. Such augmented alpha-adrenergic corollary constriction is observed during exercise and coronary interventions, and it is powerful enough to induce myocardial ischemia and limit myocardial function. Recent studies indicate a genetic determination of alpha(2)-adrenergic coronary constriction.

【 授权许可】

Free