Fractional flow reserve to determine the appropriateness of angioplasty in moderate coronary stenosis - A randomized trial

Article

关键词: ASSOCIATION TASK-FORCE;    TERM FOLLOW-UP;    ARTERY DISEASE;    MYOCARDIAL-INFARCTION;    BALLOON ANGIOPLASTY;    FUNCTIONAL SEVERITY;    MEDICAL THERAPY;    ANGIOGRAPHY;    CARDIOLOGY;    GUIDELINES;   

DOI  :  10.1161/01.CIR.103.24.2928

来源: SCIE

【 摘 要 】

Background-PTCA of a coronary stenosis without documented ischemia at noninvasive stress testing is often performed, but its benefit is unproven. Coronary pressure-derived fractional flow reserve (FFR) is an invasive index of stenosis severity that is a reliable substitute for noninvasive stress testing. A value of 0.75 identifies stenoses with hemodynamic significance. Methods and Results-In 325 patients for whom PTCA was planned and who did not have documented ischemia, FFR of the stenosis was measured. If FFR was >0.75, patients were randomly assigned to deferral (deferral group; n=91) or performance (performance group; n=90) of PTCA. If FFR was (0.75, PTCA was performed as planned (reference group; n=144). Clinical follow-up was obtained at 1, 3, 6, 12, and 24 months. Event-free survival was similar between the deferral and performance groups (92% versus 89% at 12 months and 89% versus 83% at 24 months) but was significantly lower in the reference group (80% at 12 months and 78% at 24 months). In addition, the percentage of patients free from angina was similar between the deferral and performance groups (49% versus 50% at 12 months and 70% versus 51% at 24 months) but was significantly higher in the reference group (67% at 12 and 80% at 24 months). Conclusions-In patients with a coronary stenosis without evidence of ischemia, coronary pressure-derived FFR identifies those who will benefit from PTCA.

【 授权许可】

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