Relation between Gd-DTPA contrast enhancement and regional inotropic response in the periphery and center of myocardial infarction | |
Article | |
关键词: MICROVASCULAR OBSTRUCTION; FUNCTIONAL RECOVERY; INJURY; REPERFUSION; TISSUE; SIZE; | |
DOI : 10.1161/hc3401.095113 | |
来源: SCIE |
【 摘 要 】
Background-Od-DTPA contrast-enhanced (CE) MRI identifies patterns of early hypoenhancement and delayed hyperenhancement in acute myocardial infarction, but their clinical significance for the prediction of myocardial viability remains controversial. Therefore, we closely examined the relationship between these CE patterns and regional inotropic response to low-dose dobutamine infusion at a regional level. Methods and Results-Thirteen dogs underwent CE and tagged MRI at rest and during 5 mug.kg(-1).min(-1) dobutamine 48 hours after MI. CE patterns and 3D regional strains were measured in 96 segments per animal. Segments were categorized as being normofunctional (n = 828) if resting circumferential shortening was within the range of remote myocardium, or dysfunctional (n=420) if not. Inotropic response in resting dysfunctional segments was assessed according to CE patterns. Significant improvement of radial thickening (from +12 +/- 1% [mean +/- SEM] to +22 +/- 2%, P < 0.05) and circumferential shortening (from +1
【 授权许可】
Free