Passage of inhaled particles into the blood circulation in humans

Article

关键词: PARTICULATE AIR-POLLUTION;    HEART-RATE;    PULMONARY;    LUNG;    CLEARANCE;    MORTALITY;    DIAGNOSIS;   

DOI  :  10.1161/hc0402.104118

来源: SCIE

【 摘 要 】

Background-Pollution by particulates has been consistently associated with increased cardiovascular morbidity and mortality. However, the mechanisms responsible for these effects are not well-elucidated. Methods and Results-To assess to what extent and how rapidly inhaled pollutant particles pass into the systemic circulation, we measured, in 5 healthy volunteers, the distribution of radioactivity after the inhalation of Technegas, an aerosol consisting mainly of ultrafine (99m)Technetium-labeled carbon particles (<100 nm). Radioactivity was detected in blood already at I minute, reached a maximum between 10 and 20 minutes, and remained at this level up to 60 minutes. Thin layer chromatography of blood showed that in addition to a species corresponding to oxidized Tc-99m, ie, pertechnetate, there was also a species corresponding to particle-bound Tc-99m. Gamma camera images showed substantial radioactivity over the liver and other areas of the body. Conclusions-We conclude that inhaled Tc-99m-labeled ultrafine carbon particles pass rapidly into the systemic circulation, and this process could account for the well-established, but poorly understood, extrapulmonary effects of air pollution.

【 授权许可】

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