被撤回的出版物: Multiple atherosclerotic plaque rupture in acute coronary syndrome - A three-vessel intravascular ultrasound study (Retracted article. See vol. 125, pg. E1019, 2012)

Article; Retracted Publication

关键词: ACUTE MYOCARDIAL-INFARCTION;    UNSTABLE ANGINA;    ARTERY-DISEASE;    STENOSIS PROGRESSION;    VULNERABLE PLAQUES;    ISCHEMIC DEATH;    THROMBOSIS;    DISRUPTION;    MECHANISMS;    PECTORIS;   

DOI  :  10.1161/01.CIR.0000025609.13806.31

来源: SCIE

【 摘 要 】

Background-To test the hypothesis of general atherosclerotic plaque destabilization during acute coronary syndrome (ACS), the present study sought to analyze the 3 coronary arteries by systematic intravascular ultrasound scan (IVUS). Methods and Results-Seventy-two arteries were explored in 24 patients referred for percutaneous coronary intervention after a first ACS with troponin I elevation. Fifty plaque ruptures (mean, 2.08 per patient; range, 0 to 6) were diagnosed by the association of a ruptured capsule with intraplaque cavity. Plaque rupture on the culprit lesion was found in 9 patients (37.5%). At least 1 plaque rupture was found somewhere other than on the culprit lesion in 19 patients (79%). These lesions were in a different artery than the culprit artery in 70.8% and were in both other arteries in 12.5% of these 24 patients. Complete IVUS examination of all 3 coronary axes in patients who had experienced a first ACS revealed that multiple atherosclerotic plaque ruptures were detected by IVUS; these multiple ruptures were present simultaneously with the culprit lesion; they were frequent and located (in three quarters of cases) on the 3 principal coronary trunks; and the multiple plaque ruptures in locations other than on the culprit lesion were less severe, nonstenosing, and less calcified. Conclusion-Although one single lesion is clinically active at the time of ACS, the syndrome seems nevertheless associated with overall coronary instability.

【 授权许可】

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