Outcome after implantation of a cardioverter-defibrillator in patients with Brugada syndrome - A multicenter study

Article

关键词: ST-SEGMENT-ELEVATION;    BUNDLE-BRANCH BLOCK;    VENTRICULAR-FIBRILLATION;    RISK STRATIFICATION;    SUDDEN-DEATH;    LEADS V-1;    INDIVIDUALS;    ARRHYTHMIAS;    PROGNOSIS;    PATTERN;   

DOI  :  10.1161/CIRCULATIONAHA.106.628537

来源: SCIE

【 摘 要 】

Background - Brugada syndrome is an arrhythmogenic disease characterized by an increased risk of sudden cardiac death (SCD) by ventricular fibrillation. At present, an implantable cardioverter-defibrillator (ICD) is the recommended therapy in high-risk patients. This multicenter study reports the outcome of a large series of patients implanted with an ICD for Brugada syndrome. Methods and Results - All patients (n = 220, 46 +/- 12 years, 183 male) with a type 1 Brugada ECG pattern implanted with an ICD in 14 centers between 1993 and 2005 were investigated. ICD indication was based on resuscitated SCD (18 patients, 8%), syncope (88 patients, 40%), or positive electrophysiological study in asymptomatic patients (99 patients, 45%). The remaining 15 patients received an ICD because of a family history of SCD or nonsustained ventricular arrhythmia. During a mean follow-up of 38 +/- 27 months, no patient died and 18 patients (8%) had appropriate device therapy (10 +/- 15 shocks/patient, 26 +/- 33 months after implantation). The complication rate was 28%, including inappropriate shocks, which occurred in 45 patients (20%, 4 +/- 3 shocks/patient, 21 +/- 20 months after implantation). The reasons for inappropriate therapy were lead failure (19 patients), T-wave oversensing (10 patients), sinus tachycardia (10 patients), and supraventricular tachycardia (9 patients). Among implantation parameters, high defibrillation threshold, high pacing threshold, and low R-wave amplitude occurred, respectively, in 12%, 27%, and 15% of cases. Conclusion - In this large Brugada syndrome population, a low incidence of arrhythmic events was found, with an annual event rate of 2.6% during a follow-up of > 3 years, in addition to a significant risk of device-related complications (8.9%/year). Inappropriate shocks were 2.5 times more frequent than appropriate ones.

【 授权许可】

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