Vascular endothelial growth factor-B-deficient mice display an atrial conduction defect

Article

关键词: TYROSINE KINASE;    VEGF-B;    FLT-1 RECEPTOR;    IN-VIVO;    MOUSE;    ANGIOGENESIS;    EXPRESSION;    LIGAND;    NEUROPILIN-1;    SUGGESTS;   

DOI  :  10.1161/01.CIR.104.3.358

来源: SCIE

【 摘 要 】

Background - Vascular endothelial growth factors (VEGFs) and their receptors are essential regulators of vasculogenesis and angiogenesis in both embryos and adults. One of the factors with a still unknown physiological function is VEGF-B, which is expressed in many tissues, including the heart. Methods and Results - Mice carrying a targeted deletion in the VEGF-B gene were developed. In VEGF-B animals, no gross abnormalities were observed in organs that normally show high expression of VEGF-B, such as the heart, muscle, and kidney. Analysis of heart function by ECG showed that adult VEGF-B-/- mice have an atrial conduction abnormality characterized by a prolonged PQ interval. VEGF- or basic fibroblast growth factor-induced corneal angiogenesis was similar in normal and VEGF-B-/- mice. Conclusions - VEGF-B seems to be required for normal heart function in adult animals but is not required for proper development of the cardiovascular system either during development or for angiogenesis in adults.

【 授权许可】

Free