Differential effects of interleukin-1 receptor antagonist and tumor necrosis factor binding protein on fatty-streak formation in apolipoprotein E-deficient mice

Article

关键词: ATHEROSCLEROSIS;    CELLS;    LEUKOCYTES;    EXPRESSION;    INCREASES;    MONOCYTES;    INHIBITOR;    ADHESION;   

DOI  :  10.1161/01.CIR.97.3.242

来源: SCIE

【 摘 要 】

Background-The cytokines interleukin 1 (IL-1) and tumor necrosis factor (TNF) are secreted by the different cell populations of the vascular wall and have been suggested to promote atherosclerosis, Methods and Results-Their respective roles in fatty-streak formation in apolipoprotein E-deficient mice were investigated by use of IL-1 receptor antagonist and TNF binding protein. Estradiol-17 beta was used as a positive control. Blocking TNF seemed to be active in female animals but not in males. IL-1 receptor antagonist was as effective as or more effective than estradiol in both sexes. Conclusions-IL-1 plays a crucial role in the initial step of the atherosclerotic process in this animal model, and blocking the activity of this cytokine should be considered as a therapeutic possibility.

【 授权许可】

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