Positron emission tomographic evidence of toxic effect of MDMA (Ecstasy) on brain serotonin neurons in human beings

Article

关键词: UPTAKE SITES;    (+/-)3,4-METHYLENEDIOXYMETHAMPHETAMINE MDMA;    METHYLENEDIOXYMETHAMPHETAMINE MDMA;    NONHUMAN-PRIMATES;    BABOON BRAIN;    RAT-BRAIN;    NEUROTOXICITY;    TERMINALS;    PET;    3,4-METHYLENEDIOXYMETHAMPHETAMINE;   

DOI  :  10.1016/S0140-6736(98)04329-3

来源: SCIE

【 摘 要 】

Background. (+/-)3,4-methylenedioxymethamphetamine (MDMA; Ecstasy) is, a popular recreational drug that selectively damages brain. serotonin (5-HT) neurons in animals at doses' that closely approach those used by humans. We investigated the status of brain 5-HT neurons in MDMA users. Methods We enrolled 14 previous users of MDMA who were currently abstaining from use and 15 controls who had never used MDMA. We used positron emission tomography (PET) with the radioligand carbon-11-labelled McN-5652, which selectively labels the 5-HT transporter. We analysed whether there were differences in 5-HT transporter binding between abstinent MDMA users and participants in the control group. Blood and urine samples were taken and tested to check for abstinence. Findings MDMA users showed decreased global and regional brain BHT transporter binding compared with controls. Decreases in 5-HT transporter binding positively correlated with the extent of previous MDMA use. Interpretation Quantitative PET studies with a ligand selective for 5-HT transporters can be used to assess the status of 5-HT neurons in the living human brain. We show direct evidence of a decrease in a structural component of brain 5-HT neurons in human MDMA users.

【 授权许可】

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