Type 1 diabetes

Review

关键词: BETA-CELL FUNCTION;    POPULATION-BASED COHORT;    C-PEPTIDE PRESERVATION;    ALL-CAUSE MORTALITY;    SEVERE HYPOGLYCEMIA;    DOUBLE-BLIND;    T-CELLS;    RECENT-ONSET;    ISLET TRANSPLANTATION;    YOUNG-ADULTS;   

DOI  :  10.1016/S0140-6736(18)31320-5

来源: SCIE

【 摘 要 】

Type 1 diabetes is a chronic autoimmune disease characterised by insulin deficiency and resultant hyperglycaemia. Knowledge of type 1 diabetes has rapidly increased over the past 25 years, resulting in a broad understanding about many aspects of the disease, including its genetics, epidemiology, immune and beta-cell phenotypes, and disease burden. Interventions to preserve beta cells have been tested, and several methods to improve clinical disease management have been assessed. However, wide gaps still exist in our understanding of type 1 diabetes and our ability to standardise clinical care and decrease disease-associated complications and burden. This Seminar gives an overview of the current understanding of the disease and potential future directions for research and care.

【 授权许可】

Free