Outdoor air pollution and asthma

Article

关键词: DIESEL EXHAUST PARTICLES;    NITROGEN-DIOXIDE EXPOSURE;    GREENHOUSE-GAS EMISSIONS;    TOBACCO-SMOKE EXPOSURE;    EXHALED NITRIC-OXIDE;    LUNG-FUNCTION;    OXIDATIVE STRESS;    CHILDHOOD ASTHMA;    RESPIRATORY SYMPTOMS;    AMBIENT PARTICULATE;   

DOI  :  10.1016/S0140-6736(14)60617-6

来源: SCIE

【 摘 要 】

Traffic and power generation are the main sources of urban air pollution. The idea that outdoor air pollution can cause exacerbations of pre-existing asthma is supported by an evidence base that has been accumulating for several decades, with several studies suggesting a contribution to new-onset asthma as well. In this Series paper, we discuss the effects of particulate matter (PM), gaseous pollutants (ozone, nitrogen dioxide, and sulphur dioxide), and mixed traffic-related air pollution. We focus on clinical studies, both epidemiological and experimental, published in the previous 5 years. From a mechanistic perspective, air pollutants probably cause oxidative injury to the airways, leading to inflammation, remodelling, and increased risk of sensitisation. Although several pollutants have been linked to new-onset asthma, the strength of the evidence is variable. We also discuss clinical implications, policy issues, and research gaps relevant to air pollution and asthma.

【 授权许可】

Free