Effects of pulmonary insufficiency on biventricular function in the developing heart of growing swine

Article

关键词: VENTRICULAR DIASTOLIC FUNCTION;    SYSTOLIC PRESSURE-VOLUME;    TETRALOGY;    REPAIR;    FALLOT;    PERFORMANCE;    PHYSIOLOGY;    EXERCISE;    INDEXES;    ANIMALS;   

DOI  :  10.1161/01.CIR.0000092887.84425.09

来源: SCIE

【 摘 要 】

Background - This study was conducted to determine the effects of chronic pulmonary insufficiency ( PI) on right ( RV) and left (LV) ventricular function in young growing swine. Methods and Results - Six PI and 5 control animals were studied. PI was induced by transcatheter placement of stents across the pulmonary valve. Indices of systolic function ( ejection fraction, cardiac output, and cardiac functional reserve), diastolic function ( compliance), and myocardial contractility ( the slope of the relationship of end-systolic pressure versus end-systolic volume [E-max] and the slope of the dP/dt(max) - end- diastolic volume relationship [M-dP/dt]) were assessed within 2 days of intervention and 3 months later. MRI was used to quantify PI and ventricular volumes. Conductance catheter techniques were used to obtain indices of contractility and diastolic compliance from pressure-volume relations at rest and under dobutamine infusion. In the PI group, pulmonary regurgitant fraction was 49.2 +/- 5.9% at 3-month follow-up. RV cardiac functional reserve was limited, diastolic function was preserved, and myocardial contractility was altered (E-max = 2.6 +/- 0.3 mm Hg/ mL for the PI group versus 3.5 +/- 0.4 mm Hg/mL for control; P < 0.01). LV cardiac functional reserve was limited, ventricular compliance decreased, and myocardial contractility was preserved. Conclusions - In the young developing heart, chronic PI alters biventricular systolic function, RV myocardial contractility, and LV diastolic performance.

【 授权许可】

Free