Patients with type 3 severe von Willebrand disease are not protected against atherosclerosis - Results from a multicenter study in 47 patients

Article

关键词: INTIMA-MEDIA THICKNESS;    SEVERE VONWILLEBRANDS DISEASE;    ARTERIAL-WALL;    CORONARY ATHEROSCLEROSIS;    PLATELET-AGGREGATION;    AUTOPSY FINDINGS;    CAROTID-ARTERY;    PIGS;    SUBENDOTHELIUM;    ULTRASOUND;   

DOI  :  10.1161/01.CIR.0000112567.53841.10

来源: SCIE

【 摘 要 】

Background - The results of a number of studies in pigs and mice suggest that absence of von Willebrand factor (vWF) protects against the development of atherosclerosis. We studied whether patients with a complete deficiency of vWF ( type 3 von Willebrand disease [vWD]) develop fewer atherosclerotic vessel wall changes than healthy controls. Methods and Results - This study included 47 individuals with type 3 vWD and 84 healthy controls. Early atherosclerotic changes were assessed by measuring the thickness of the intima-media in the carotid and femoral arteries by B-mode ultrasonography. Advanced atherosclerotic changes were quantified by summing the maximal thickness of atherosclerotic plaques in the carotid and femoral arteries and were expressed as a plaque score. Established risk factors were determined to adjust for possible differences between the groups. We found no substantial difference in intima-media thickness between vWD patients and controls ( adjusted difference for carotid artery 0.007 mm, 95% CI - 0.022 to 0.036 mm; femoral artery 0.069 mm, 95% CI - 0.056 to 0.19 mm). Similar proportions of patients and controls had atherosclerotic plaques (19% and 17%, respectively). No difference was found in the plaque score between groups ( adjusted difference - 0.22 mm, 95% CI - 0.69 to 0.26). Among vWD patients, we found no effect of treatment with vWF concentrates on intima-media thickness or plaque score. Conclusions - The results of this study indicate that vWF does not play a substantial role in human atherogenesis.

【 授权许可】

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