Quantitative assessment of the effect of angiotensinogen gene Polymorphisms on the risk of coronary heart disease

Article

关键词: I-CONVERTING-ENZYME;    MYOCARDIAL-INFARCTION;    ARTERY-DISEASE;    BLOOD-PRESSURE;    PLASMA ANGIOTENSINOGEN;    CARDIOVASCULAR-DISEASE;    M235T POLYMORPHISM;    TYPE-1 RECEPTOR;    SYSTEM GENES;    ASSOCIATION;   

DOI  :  10.1161/CIRCULATIONAHA.107.728857

来源: SCIE

【 摘 要 】

Background - Angiotensinogen, a key protein in the renin-angiotensin system, plays an important role in cardiovascular hemostasis. Many studies have examined the association between polymorphisms in the angiotensinogen gene and risk of coronary heart disease ( CHD), but the results have been inconsistent. Methods and Results - We performed a meta-analysis of 43 associations studies on 2 angiotensinogen polymorphisms (M235T and T174M) and risk of CHD published before March 2007, including a total of 13 478 CHD cases and 17 024 controls. We also explored potential sources of heterogeneity. In a combined analysis, the summary per-allele odds ratio for CHD of the M235T polymorphism was 1.11 ( 95% confidence interval, 1.03 to 1.19). However, when the analyses were restricted to 4 larger studies (n > 500 cases), the summary per-allele odds ratio was 0.99 ( 95% confidence interval, 0.94 to 1.04). Our analyses detected a possibility of publication bias with an overestimate of the true association by smaller studies. A meta-analysis of studies on the 174M variant showed no significant overall association with CHD, yielding a per-allele odds ratio of 1.07 ( 95% confidence interval, 0.93 to 1.22). Conclusions - This meta-analysis suggested an overall weak association between the M235T polymorphism and CHD risk. However, the association was not observed in several larger studies, suggesting a publication bias. Additional very large-scale studies are warranted to provide conclusive evidence on the effects of the angiotensinogen gene and other genes within the renin-angiotensin system on risk of CHD.

【 授权许可】

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