Environmental risk factors for type 1 diabetes

Article

关键词: CALMETTE-GUERIN VACCINATION;    BETA-CELL AUTOIMMUNITY;    HLA-CONFERRED SUSCEPTIBILITY;    ENDOPLASMIC-RETICULUM STRESS;    CAPSID PROTEIN VP1;    EARLY WEIGHT-GAIN;    ISLET AUTOIMMUNITY;    ENTEROVIRUS INFECTION;    DRINKING-WATER;    GUT MICROBIOTA;   

DOI  :  10.1016/S0140-6736(16)30507-4

来源: SCIE

【 摘 要 】

The incidence of type 1 diabetes has risen considerably in the past 30 years due to changes in the environment that have been only partially identified. In this Series paper, we critically discuss candidate triggers of islet autoimmunity and factors thought to promote progression from autoimmunity to overt type 1 diabetes. We revisit previously proposed hypotheses to explain the growth in the incidence of type 1 diabetes in light of current data. Finally, we suggest a unified model in which immune tolerance to beta cells can be broken by several environmental exposures that induce generation of hybrid peptides acting as neoautoantigens.

【 授权许可】

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