Leishmaniasis

Article

关键词: INDIAN VISCERAL LEISHMANIASIS;    CUTANEOUS LEISHMANIASIS;    MUCOCUTANEOUS LEISHMANIASIS;    CYTOKINE RESPONSES;    NATURAL-HISTORY;    KALA-AZAR;    DIAGNOSIS;    CELL;    DNA;    GUATEMALA;   

DOI  :  10.1016/S0140-6736(98)10178-2

来源: SCIE

【 摘 要 】

In 1903, Leishman and Donovan separately described the protozoan now called Leishmania donovani in splenic tissue from patients in India with the life-threatening disease now called visceral leishmaniasis. Almost a century later, many features of leishmaniasis and its major syndromes (ie, visceral, cutaneous, and mucosal) have remained the same; but also much has changed. As before, epidemics of this sandfly-borne disease occur periodically in India and elsewhere; but leishmaniasis has also emerged in new regions and settings, for example, as an AIDS-associated opportunistic infection. Diagnosis still typically relies on classic microbiological methods, but molecular-based approaches are being tested. Pentavalent antimony compounds have been the mainstay of antileishmanial therapy for half a century, but lipid formulations of amphotericin B (though expensive and administered parenterally) represent a major advance for treating visceral leishmaniasis. A pressing need is for the technological advances in the understanding of the immune response to leishmania and the pathogenesis of leishmaniasis to be translated into field-applicable and affordable methods for diagnosis, treatment, and prevention of this disease.

【 授权许可】

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