Pathophysiology, research challenges, and clinical management of smoke inhalation injury

Review

关键词: ACUTE LUNG INJURY;    RESPIRATORY-DISTRESS-SYNDROME;    ATTENUATES PULMONARY PATHOPHYSIOLOGY;    FREQUENCY PERCUSSIVE VENTILATION;    EXTRACORPOREAL CO2 REMOVAL;    BRONCHIAL BLOOD-FLOW;    GENE-RELATED PEPTIDE;    LOW TIDAL VOLUME;    OVINE MODEL;    BURN INJURY;   

DOI  :  10.1016/S0140-6736(16)31458-1

来源: SCIE

【 摘 要 】

Smoke inhalation injury is a serious medical problem that increases morbidity and mortality after severe burns. However, relatively little attention has been paid to this devastating condition, and the bulk of research is limited to preclinical basic science studies. Moreover, no worldwide consensus criteria exist for its diagnosis, severity grading, and prognosis. Therapeutic approaches are highly variable depending on the country and burn centre or hospital. In this Series paper, we discuss understanding of the pathophysiology of smoke inhalation injury, the best evidence-based treatments, and challenges and future directions in diagnostics and management.

【 授权许可】

Free