Effects of spaceflight on the muscles of the murine shoulder

Article

关键词: ROTATOR CUFF TEARS;    SKELETAL-MUSCLE;    STATISTICAL-MODEL;    STRENGTH;    MICROGRAVITY;    MOUSE;    SUPRASPINATUS;    ARCHITECTURE;    ADAPTATIONS;    GENDER;   

DOI  :  10.1096/fj.201700320R

来源: SCIE

【 摘 要 】

Mechanical loading is necessary for the development and maintenance of the musculoskeletal system. Removal of loading viamicrogravity, paralysis, or bed rest leads to rapid loss of muscle mass and function; however, the molecular mechanisms that lead to these changes are largely unknown, particularly for the spaceflight (SF) microgravity environment. Furthermore, few studies have explored these effects on the shoulder, a dynamically stabilized joint with a large range of motion; therefore, we examined the effects of microgravity on mouse shoulder muscles for the 15-d Space Transportation System (STS)-131, 13-d STS-135, and 30-d Bion-M1 missions. Mice from STS missions were euthanized within 4 h after landing, whereas mice from the Bion-M1 mission were euthanized within 14 h after landing. The motion-generating deltoid muscle was more sensitive to microgravity than the joint-stabilizing rotator cuff muscles. Mice from the STS-131 mission exhibited reduced myogenic (Myf5 and -6) and adipogenic (Pparg, Cebpa, and Lep) gene expression, whereas either no change or an increased expression of these genes was observed in mice from the Bion-M1 mission. In summary, muscle responses to microgravity were muscle type specific, short-duration SF caused dramatic molecular changes to shoulder muscles and responses to reloading uponlanding were rapid.

【 授权许可】

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