Pathways towards and away from Alzheimer's disease

Review

关键词: AMYLOID PRECURSOR PROTEIN;    PRESENILIN-1 TRANSGENIC MICE;    CENTRAL-NERVOUS-SYSTEM;    REVERSIBLE MEMORY LOSS;    NECROSIS-FACTOR-ALPHA;    A-BETA;    SECRETASE CLEAVAGE;    CELL-DEATH;    NEURODEGENERATIVE DISORDERS;    SYNAPTIC PLASTICITY;   

DOI  :  10.1038/nature02621

来源: SCIE

【 摘 要 】

Slowly but surely, Alzheimer's disease ( AD) patients lose their memory and their cognitive abilities, and even their personalities may change dramatically. These changes are due to the progressive dysfunction and death of nerve cells that are responsible for the storage and processing of information. Although drugs can temporarily improve memory, at present there are no treatments that can stop or reverse the inexorable neurodegenerative process. But rapid progress towards understanding the cellular and molecular alterations that are responsible for the neuron's demise may soon help in developing effective preventative and therapeutic strategies.

【 授权许可】

Free