A molecular atlas of cell types and zonation in the brain vasculature

Article

关键词: MESENCHYMAL STEM-CELLS;    BMX TYROSINE KINASE;    ENDOTHELIAL-CELLS;    GENE-EXPRESSION;    BARRIER TRANSPORT;    BLOOD-FLOW;    RNA-SEQ;    PERICYTES;    ORIGIN;    EFFLUX;   

DOI  :  10.1038/nature25739

来源: SCIE

【 摘 要 】

Cerebrovascular disease is the third most common cause of death in developed countries, but our understanding of the cells that compose the cerebral vasculature is limited. Here, using vascular single-cell transcriptomics, we provide molecular definitions for the principal types of blood vascular and vessel-associated cells in the adult mouse brain. We uncover the transcriptional basis of the gradual phenotypic change (zonation) along the arteriovenous axis and reveal unexpected cell type differences: a seamless continuum for endothelial cells versus a punctuated continuum for mural cells. We also provide insight into pericyte organotypicity and define a population of perivascular fibroblast-like cells that are present on all vessel types except capillaries. Our work illustrates the power of single-cell transcriptomics to decode the higher organizational principles of a tissue and may provide the initial chapter in a molecular encyclopaedia of the mammalian vasculature.

【 授权许可】

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